Mass Spectrometry and Chromatography

Recent Developments in Chromatography

On-going developments in fast and two-dimensional chromatographic techniques and their applications in the gas chromatography and liquid chromatography analyses of contaminants and chemical residues in foods. Two-dimensional gas chromatography or liquid chromatography separations involve the use of two coupled columns of different selectivity to provide improved separation for sections of one-dimensional chromatogram or for the whole first dimension separation. The chapter reviews some current approaches to overcome matrix effects that may adversely affect the quantitative gas chromatography- and liquid chromatography-mass spectrometric analyses of trace components in food matrices. Basic approaches to fast liquid chromatography are very similar to fast gas chromatography approaches. Differences exist because of a simple fact that liquid chromatography employs liquid and not gaseous mobile phases.