Other separation techniques combined with mass spectrometer

Most materials in our surroundings are mixtures of two or more substances and this mixture might be homogenous or heterogeneous. Most of these mixtures can be separated by some specific separation technique depends upon the type of mixture and physical and chemical properties of the mixture. Mass spectrometry combining with other techniques and plays one of the important roles in the field of separation technique when it is tandem with chromatographic and other separation technique. For simple mixtures of compounds Gas Chromatography- Mass spectrometry (GC-MS) method are used in which the component in the mixture is vaporised and then it  is separated and it is based on their affinity difference in bonded phase. For thermally unstable Liquid chromatography-Mass Spectrometry (LC-MS) is generally used which is based on the difference in affinity of samples with stationary phase and the mobile phase which is liquid phase capillary Electrophoresis-Mass Spectrometry  (CE-MS) is a new technique in which liquid separation process of capillary electrophoresis with mass spectrometry works together. Ion Mobility Spectrometry-Mass Spectrometry (IMS/MS or IMMS) is a hyphenated separation process in which ions are first separated according to their mobility and then by Mass-to-charge ratio i.e. mass spectrometry method.


  • Full scan Mass spectrometry
  • Selective ion monitoring spectrometry
  • Thermal desorption mass spectrometry and chromatography
  • Selected ion monitoring of mass spectrometry

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